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Muscle Proteomics Group

GROUP MEMBERS

  • Assistant Professor Nicole Beard (Leader)
  • Mrs Amanda Denniss (Honours student)
  • Ms Melissa Obst (Honours student)
  • Mr Brodie Yelds (Honours student)
  • Ms Weilan Mo (visiting PhD student, co-supervised at QUT/UQ)
  • Mr Spenser Richardson (visiting PhD student, co-supervised at JCSMR, ANU)

Photo of the Muscle Proteomics Group researchers

RESEARCH THEMES

Research within the Muscle Proteomics Group is focussed on understanding how intracellular calcium signalling pathways initiate muscle contraction. We explore and define the mechanisms which lead to control of calcium signalling and the way in which these are disrupted in skeletal myopathies, cardiomyopathies and heart failure.

CURRENT RESEARCH PROJECTS

  • Defining the mechanisms that lead to cardiotoxicity due to common breast cancer chemotherapeutic treatment.
  • Understanding the triggers for fatal arrhythmia in patients with heart failure.
  • Uncovering the mechanisms leading to calcium overload  and muscle weakness in sarcopenic how disrupted communication between proteins in the luminal calcium stores leads to skeletal myopathy in patients treated with statins (high cholesterol drugs).
  • Determining how disrupted communication between proteins in the luminal calcium stores leads to skeletal myopathy in patients treated with statins (high cholesterol drugs).

Image of a Representative trace illustrating single cell cardiomyocyte contractility
(A) Representative trace illustrating single cell cardiomyocyte contractility.  (B) Representative single ryanodine receptor ion channel activity, illustrating excess activity and calcium release upon treatment with chemotherapeutic agent doxorubicin. Channel activity is shown as upward inflections of the solid baseline.

COLLABORATIONS

  • Professor Angela Dulhunty (JCSMR, ANU)
  • Professor Bob Dirksen (U Rochester USA)
  • Professor Derek Laver (U Newcastle)
  • Professor Feliciano Protasi (U. Chieti, Italy)
  • Associate Professor Peter Molenaar (QUT)
  • Associate Professor Johanna Lanner (Karolinska Institute, Sweden)
  • Professor Paul Smith (The Canberra Hospital)
  • Dr Narora Etxebarria (UC)
  • Professor Roland Goecke (UC)
  • Professor David Pyne (AIS)

CURRENT RESEARCH FUNDING

  • RyR1 foundation