Assistant Professor in Immunology
Chair of the Animal Ethics Committee

University of Canberra ACT 2601 Australia Building 3, Room 3D39 - [Campus Map] Phone: (02) 6201 2243 Fax:     (02) 6201 5763 email: firstname.lastname@canberra.edu.au

Education

1996 PhD (Virology), University of Freiburg, Germany
1992 Diplom (Zoology, Physiology and Biochemistry), University of Osnabrück, Germany

Research and Professional Interests

Michael Frese has studied the biological activities of interferons as part of the innate immune response to virus infections in leading laboratories around the world such as the Universities of Freiburg and Heidelberg (both Germany), the Pasteur Institute in Paris (France), the Scripps Research Institute in La Jolla (California) and at the Australian National University. He is specifically interested in Mx protein-mediated antiviral resistance, interferon-induced ADAR proteins and RNA editing and animal (mouse) models for influenza and flavivirus pathogenesis.

Michael chairs the Committee for Ethics in Animal Experimentation (CEAE) at the University of Canberra, is a Fellow of the Fellow of the Australian Society for Microbiology (FASM) and a Member of the German Hepatitis Network (HepNet).

Teaching Interests

Michael is Course Convener for the Bachelor of Medical Science and Unit Convener for
Introduction to Microbiology and Immunology. He also promotes science outside the university, e.g. by organising microbiology projects for primary schools and participating in science fairs.

Recent Publications

Kaderali, L., Dazert, E. Zeuge, U., Frese M. and Bartenschlager R. (2009). Reconstructing signaling pathways from RNAi phenotypes using Boolean networks with probabilistic threshold functions. Bioinformatics 25:2229-2235.

Frese, M. and Dazert, E. (2008). Interferon-induced effector proteins and hepatitis C virus replication. In: E. Jirillo (eds), Hepatitis C virus Disease: Immunobiology and Clinical Application. Springer, New York, USA: 106-129.

Frese, M. and Bartenschlager, R. (2006). Inhibition of hepatitis C virus by nucleic acid-based antiviral approaches. In: E. Bogner and A. Holzenburg (eds.), New Concepts of Antiviral Therapy. Springer, Dordrecht, The Netherlands: 47-86.

Windisch, M.P., Frese, M., A. Kaul, A., Trippler, M., Lohmann V. and Bartenschlager, R. (2005). Dissecting the IFN-induced inhibition of hepatitis C virus replication by using a novel host cell line. Journal of Virology 79:13778-13793.

Pietschmann, T., Frese, M. and Bartenschlager, R. (2004). Novel insights into hepatitis C virus replication and persistance. Advances in Virus Research 63: 171-180.

Krönke, M., Kittler, R., Buchholz, F., Windisch, M.P., Pietschmann, T., Bartenschlager, R. and Frese, M. (2004). Alternative approaches for efficient inhibition of hepatitis C virus RNA replication. Journal of Virology 78:3436-3446.

Mihm, S., Frese, M., Meier, V., Wietzke-Braun, P., Scharf, J.-G., Bartenschlager, R. and  Ramadori, G. (2004). Interferon type I gene expression in hepatitis C virus infection. Laboratory Investigations 84:1148-1159.

Frese, M., Barth, K., Kaul, A., Lohmann, V., Schwärzle, V. and Bartenschlager, R. (2003). Hepatitis C virus RNA replication is resistant to tumor necrosis factor-α. Journal of General Virology 84:1253-1259.

Frese, M., Schwärzle, V., Barth, K., Krieger, N., Lohmann, V., Mihm, S., Haller, O. and Bartenschlager, R. (2002). Interferon-gamma inhibits subgenomic and genomic hepatitis C virus replicons. Hepatology 35:694-703 (cover story).

Wichmann, D., Gröne, H.-J., Frese, M., J. Pavlovic, B. Anheier, O. Haller, H.-D. Klenk and H. Feldmann (2002). Hantaan virus infection causes an acute neurological fatal disease in adult laboratory mice. Journal of Virology 76:8890-8899.

Frese, M., Pietschmann, T., Moradpour, D., Haller, O. and Bartenschlager, R. (2001). Interferon-alpha inhibits hepatitis C virus subgenomic RNA replication by an MxA-independent pathway. Journal of General Virology 82: 723-733.

Sandrock, M., Frese, M., Haller, O. and Kochs, G. (2001). Interferon-induced rat Mx proteins confer resistance to Rift Valley fever virus and other arthropod-borne viruses. Journal of Interferon and Cytokine Research 21: 663-668.

Ritter, M., Bolouy, M., Vialat, P., Janzen, C., Haller O. and Frese, M. (2000). Rift Valley fever virus resistance in Rattus norvegicus: genetic variability within certain "inbred" strains. Journal of General Virology 81: 2683-2688.

Frese, M., Prins, M., Ponten, A., Goldbach, R.W., Haller O. and Zeltz P. (2000). Constitutive expression of human MxA protein in transgenic tobacco plants does not confer resistance to a variety of RNA viruses. Transgenic Research 9/6: 429-438.

Hefti, H.P., Frese, M., Landis, H. Di Paolo, C., Aguzzi, A., Haller O. and Pavlovic, J. (1999). Human MxA protein protects mice lacking a functional alpha/beta interferon system against La Crosse virus and other lethal virus infections. Journal of Virology 73: 6984-6991.