Asthma and Inflammatory Disease

NHMRC RD Wright Fellow
Phone: + 61 2 62015364
Email: Michael.Rolph@canberra.edu.au

Research Interests

• Discovery of novel inflammatory disease genes
• Airway epithelium and allergic lung disease
• Airway epithelium and respiratory virus infection
• Links between inflammatory and metabolic disease

Representative Publications

Maslowski KM, Vieira AT, Ng A, Kranich J, Sierro F, Yu D, Schilter HC, Rolph MS, Mackay F, Artis D, Xavier RJ, Teixeira MM, Mackay CR (2009). Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43. Nature 461:1282-6.

Shum BOV, Mackay CR, Gorgun CZ, Frost M, Kumar RK, Hotamisligil GS, Rolph MS (2006). Requirement for adipocyte fatty acid binding protein aP2 in allergic airway inflammation. J. Clin. Invest. 116:2183-92.

Rolph MS, Young TR, Shum BOV, Gorgun CZ, Ramshaw IA, Hotamisligil GS, Mackay CR (2006). Regulation of dendritic cell function and T cell priming by the fatty acid binding protein aP2. J. Immunol. 177:7794-7801.

Jeffrey KL, Brummer T, Rolph MS, Liu SM, Callejas NA, Grumont RJ, Gillieron C, Mackay F, Grey ST, Camps M, Rommel C, Gerondakis S, Mackay CR (2006). Dual specificity phosphatase DUSP2/PAC-1 is a key positive regulator of immune cell function and inflammatory responses. Nature Immunology. 7:274-83.

Koebernick, H., Grode, L., David, J. R., Rohde, W., Rolph MS, Mittruecker, H. W., Kaufmann, S. H. E. (2002). Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium. Proc. Natl. Acad. Sci USA 99:13681-6.

Dorner, B., Scheffold, A, Rolph MS, Kaufmann, S. H. E., Radbruch, A., Flesch, I. E. A., Kroczek, R. (2002) ATAC, MIP-1?, MIP-1?, RANTES and IFN? represent a T1 functional group of cytokines released by cells of the innate and adaptive immune systems. Proc. Natl. Acad. Sci. USA 99:6181-6.

Abbreviated CV

Employment History

1992 Research Assistant, Department of Endocrinology, Prince of Wales Hospital, Sydney

1993-1997 PhD student, JCSMR, ANU

1997-2000 Postdoctoral Fellow, Max Planck Institute for Infection Biology, Berlin

2000-2001 Research Fellow, Heart Research Institute, Sydney

2001-2008 Research Fellow, Garvan Institute of Medical Research

Academic Degrees

1991 Bachelor of Medical Science (Hons), University of Tasmania

1997 PhD, Australian National University

Prizes, Scholarships, Fellowships and Awards

1997-2000 Max Planck Postdoctoral Fellowship

2003-2007 NHMRC Industry Fellowship

2008-2011 NHMRC RD Wright Fellowship